Interestingly, differences were observed in the usage of chemokine receptors with significantly increased expression of CXCR3, CCR7 and CCR2 (* p = 0.004, ** p < 0.003 and * p = 0.04, respectively) in ACPA+ compared to ACPA− RA, highlighting potentially fundamental differences in immune cell recruitment between for the two endotypes of disease (Figure 6D). Here, PRTN3 is linked to rheumatoid arthritis.