In order to futher deliniate the differnces in synovial tissue pathogenesis of ACPA− and ACPA+ RA we performed differential gene expression and pathway enrichment analysis of RNAseq data from 14 ACPA− and 32 ACPA+ RA patient synovial biopsies from study GSE89408 using the DESeq2 pipeline in R [19]. Here, PRTN3 is linked to rheumatoid arthritis.