Despite the discrepancy between proinflammatory cytokines and enrichment of T cell specific pathways in ACPA+ compared to ACPA− RA, GM-CSF, IFN-γ and TNF-α showed, log2 fold changes indicating increased expression in ACPA− compared to ACPA+ RA synovial tissue biopsies highlighting the need for further characterization of T cell responses in RA depending on ACPA status. The gene discussed is TNF; the disease is rheumatoid arthritis.