HDAC-1 overexpression has been correlated with poor survival in mobile tongue SCC [25], gastric [29,41] and colorectal carcinoma [42], intrahepatic cholangiocarcinoma [43] and urothelial bladder endometrial and ovarian carcinoma [38], especially of endometrioid type [37,44]. The gene discussed is HDAC1; the disease is intrahepatic cholangiocarcinoma.