Phloridzin has been shown to lack specificity for SGLT2, and phloridzin has been reported previously to improve hyperglycemia through the reduction of the blood glucose level and reverse the streptozotocin-mediated induction of SGLT1 rather than SGLT2 in the small intestine in streptozotocin-induced diabetic mice [17,32,33,34]. This evidence concerns the gene SLC5A1 and Hyperglycemia.