Taken together, our results indicate that the expression of ABCB1 was important for cellular responses to sTRAIL, and that inhibition of ABCB1 efflux activity boosted the effectiveness of sTRAIL-mediated cell death, forming a case for a closer examination of combination therapies of TRAIL and ABCB1 inhibitors in docetaxel-resistant PCa. The gene discussed is TNFSF10; the disease is posterior cortical atrophy.