Since alterations in androgen receptor (AR) signaling are known to be critical in PCa progression, and resistance to docetaxel has been associated with deregulated AR signaling [14,15], we specifically examined the expression pattern of nine canonical AR target genes (KLK3, TMPRSS2, NK3X-1, KLK2, AMACR, CDC2O, CDK1, FKBP5, and ACADSB) in our docetaxel-resistant sub-lines. This evidence concerns the gene KLK3 and posterior cortical atrophy.