IRF8 and inflammatory bowel disease: 1.4-fold increases in Stat1 (p = 5.00 × 10−5) and Irf8 (p = 5.00 × 10−5), 2-fold (p = 5.00 × 10−5) increases in granzyme b (Gzmb) and immunity-related GTPase family M member 1 (Irgm1) and a 1.6-fold (p = 5.00 × 10−5) up-regulation of the Interferon Inducible Protein 47 gene (IFI47) were observed in S89A mice consistent with the known IFN/STAT1 pathway dysregulation in IBD [47].