Because most typical retinal findings of IFN-associated retinopathy, including cotton wool spots and retinal hemorrhage, are benign and reversible, referring only patients with subjective vision changes to ophthalmologists for fundus examination is reasonable, instead of performing routine fundus examination during the PegIFN/RBV treatment course to prevent severe ocular ischemic events, just as patients without HCV would be evaluated. The gene discussed is IFNA1; the disease is retinal disorder.