EMP2 and non-small cell lung carcinoma: Compared to human bronchial epithelial cells (HBEC), EMP1 was significantly downregulated in nine out of ten NSCLC cell lines and decreased expression of EMP2 was found in six out of ten cell lines, while EMP3 was upregulated in more than half (six out of ten) of NSCLC cell lines (Figure 1A).