IFNG and infection: Furthermore, BUD came into focus during the SARS-CoV-2 pandemic, and it was examined in coronavirus HCoV-229E infection, where it was found to decrease the expression of the viral entry receptor and infection-induced cytokines, especially interleukin (IL)-6, IL-8, and interferon (IFN)-γ, resulting in inhibited viral replication in vitro [9].