The main goals of this work are, to report normative thickness data for both the C57BL6/129S (Wild-Type; WT) and the triple transgenic (3×Tg-AD) mice, harbouring three human genes: Swedish amyloid precursor protein (APPswe), presenilin 1 (PSEN1), and microtubule-associated protein tau (MAPT), which are associated with familial Alzheimer's disease. The gene discussed is PSEN1; the disease is familial Alzheimer disease.