Similar examples of genes with fine-mapped loss- or partial-loss-of-function autoimmune-disease risk alleles included IL18RAP (MIM: 604509), ITGAM (MIM: 120980), MST1 (MIM: 142408), RNF186 (MIM: 617163), TRAF3IP2 (MIM: 607043), and CD58 (MIM: 153420),32,35, 36, 37,41,45,46,48 implying agonists of the protein products of these genes as potential therapeutic interventions (Figure 4C and Tables S6 and S7). This evidence concerns the gene IL18RAP and autoimmune disease.