YAP1 and melanoma: ,30 Results of YAP/TAZ inhibition in cutaneous melanoma are mixed: one study identified diminished cell growth in cutaneous melanoma cell lines after administration of VP but found no effect on tumor development or tumor growth in a mouse model,39 whereas another study found no effect of YAP/TAZ inhibition using shRNA on in vitro proliferation, but identified decreased in vitro invasiveness and less metastases formation after injection of melanoma cells in mice.40