,30 Results of YAP/TAZ inhibition in cutaneous melanoma are mixed: one study identified diminished cell growth in cutaneous melanoma cell lines after administration of VP but found no effect on tumor development or tumor growth in a mouse model,39 whereas another study found no effect of YAP/TAZ inhibition using shRNA on in vitro proliferation, but identified decreased in vitro invasiveness and less metastases formation after injection of melanoma cells in mice.40 Here, WWTR1 is linked to cutaneous melanoma.