For example, gene ARHGEF2 on chromosome 1(with FDR = 2.46×10−13) is shown to be interact with all four members of the MARK family including MARK4 on chromosome 19 which has an emerging tole in the phosphorylation of MAPT/TAU in Alzheimer’s disease and identified by VC-TWAS using cis-eQTL DPR weights [56]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.