By using the filtered cis-eQTL DPR weights, we identified 57 significant risk genes with FDR <0.05 by VC-TWAS (Fig 3A; S3 Table and S11A Fig), including the most well-known AD risk genes TOMM40 and APOE, along with 45 genes that were located within ~2MB region around those two risk genes. This evidence concerns the gene TOMM40 and Alzheimer disease.