APOE and Alzheimer disease: We also applied VC-TWAS with PrediXcan weights, but no significant genes were identified with FDR <0.05 (S8, S9 and S10 Figs), neither the genes with smallest p-values were proximal to APOE. In contrast, our results by VC-TWAS with filtered DPR weights provided potential biological interpretations for several known AD risk genes via gene expression and for their associations with both clinical and pathologic AD phenotype.