By considering only cis-eQTL effect sizes, VC-TWAS identified both novel and known risk genes for AD within 2MB of the well-known major risk gene APOE of AD, including the known risk gene TOMM40 and APOE. Considering both cis- and trans- eQTL effect sizes estimated by the Bayesian Genome-wide TWAS (BGW-TWAS) method [30], VC-TWAS detected 71 risk genes for AD which complemented existing TWAS results using only cis-eQTL SNP data. The gene discussed is APOE; the disease is Alzheimer disease.