ZNF234 and Alzheimer disease: For example, the top significant gene ZNF234 (with FDR = 1.40×10−12) by meta VC-TWAS of AD clinical diagnosis is also the top significant gene (p-value = 2.10×10−4) by VC-TWAS of β-amyloid, the second most significant gene (p-value = 6.39×10−5) by VC-TWAS of global AD pathology, and has p-value = 1.06×10−3 by VC-TWAS of tangles.