TOMM40 and Alzheimer disease: Another significant gene of interest is TOMM40, which has FDR = 2.86×10−9 by meta VC-TWAS for AD dementia and VC-TWAS p-values = (4.44×10−4, 6.95×10−2, 1.91×10−4) for β-amyloid, tangles, and global AD pathology, respectively.