Interestingly, despite the rescue from cyst development, additional deletion of Ripk1 did not significantly alter ALT, GLDH, and AP serum levels (Fig. 4F and SI Appendix, Fig. S4C) but led to a significant reduction of the necrotic areas compared with JNK1/2LPC-KO animals, suggesting ameliorated but ongoing hepatocellular damage (SI Appendix, Fig. S4D). The gene discussed is MAPK8; the disease is cyst.