In contrast, this was not seen in patients with autosomal dominant or autosomal recessive variants of polycystic disease and biliary microhamartoma (von Meyenburg complex) (Fig. 7 D and E and SI Appendix, Table S2), suggesting that RIPK1 might play a specific role in the pathogenesis of hepatic cyst formation, as it does in mice with JNK1/2-deficient cholangiocytes. This evidence concerns the gene MAPK8 and Hepatic cysts.