In order to test the functional interaction of RIPK1 with CASPASE-8 in cyst formation of JNK1/2LPC-KO mice, we intercrossed JNK1/2/RIPK1LPC-KO mice with Caspase-8FL mice (JNK1/2/RIPK1/CASP-8LPC-KO) (SI Appendix, Fig. S4A). Here, MAPK8 is linked to cyst.