MAPK8 and cyst: While JNK1/2LPC-KO mice showed liver injury to a certain degree, we did not detect a significant alteration of overall liver injury measured by serum enzymes like ALT, GLDH, or AP when we additionally deleted Mlkl (blockage of necroptosis; tendency to more cyst development), Caspase-8 [blockage of apoptosis and potential activation of necroptosis (19); tendency to less cyst development], or Ripk1 [inhibition of necroptosis/potential activation of apoptosis (24); rescue from cyst development] (Fig. 4).