To test if this unexpected cyst phenotype was independent of this specific cre line, we next regenerated conditional JNK1/2-knockout mice (JNK1/2Δhep) with an alternative cre line widely used in the field, namely the albumin-cre line, which targets the same albumin-expressing cell compartment as the alfp promotor (17) (SI Appendix, Fig. S2C). This evidence concerns the gene MAPK8 and cyst.