MAPK8 and cyst: Based on the finding that—despite no changes in the overall degree of spontaneous liver injury measured by serum levels of liver enzymes like ALT—hepatic cyst development was not substantially influenced by genetic modifications of either Caspase-8 or Mlkl alone, we hypothesized that targeting simultaneously both cell-death pathways through additional deletion of Ripk1 in JNK1/2LPC-KO mice might rescue cyst formation (SI Appendix, Fig. S4A).