Right‐sided tumors are more likely to express BRAF mutations, have MMRd, and CpG island methylator phenotype (CIMP) mutations, while LCC is more associated with K‐RAS mutations, chromosomal instability, and defective tumor suppressors (p53, adenomatous polyposis coli [APC], and Deleted in Colon Cancer [DCC]).27, 28. The gene discussed is TP53; the disease is leukoencephalopathy with calcifications and cysts.