In HD mouse models, peripheral KMO inhibition improves disease‐relevant phenotypes (Beaumont et al., 2016; Zwilling et al., 2011), while genetic inhibition is strongly protective in HD model yeast (Giorgini et al., 2005) and Drosophila (Breda et al., 2016; Campesan et al., 2011; Green et al., 2012). Here, KMO is linked to Huntington disease.