In clear cell RCC, PD-L1 expression in cancer cells and immune cells was related to adverse tumor features, including high ISUP (p ≤ 0.0010), high Fuhrmann (p ≤ 0.0030), and high Thoenes grade (p ≤ 0.0020) as well as short recurrence-free (p < 0.0001) and reduced overall survival (p ≤ 0.0030). Here, CD274 is linked to cancer.