Only few studies have earlier studied multiple RCC subtypes [18, 24, 26, 28, 49, 50] and the existing data on differences in PD-L1 expression between RCC subtypes are conflicting. Our observations are in line with studies that have also reported lower rates of PD-L1 positivity in clear cell compared to papillary (0–16% vs 27–32% [18, 26]) or in chromophobe RCC (0% vs 35% [18]). This evidence concerns the gene CD274 and renal cell carcinoma.