Combination therapy with azacitidine and ABT-737, an inhibitor of BCL2, BCLXL, and BCLW, not only displayed synergistic killing of AML cells but also decreased tissue invasion of leukemic cells in vivo, thus dampening a potential niche microenvironment-based evasion mechanism of resistance in AML[164]. Here, BCL2 is linked to acute myeloid leukemia.