Biodegradable photoluminescent poly (lactic acid) (BPLP-PLA) were loaded with anti-BRAF V600E mutant melanoma specific drug (PLX4032) and conjugated with muramyl tripeptide (MTP) (MTP-BPLP-PLA-PLX4032), which were internalized in THP-1 macrophage cells. This evidence concerns the gene OPRPN and melanoma.