Loss of ASXL1 leads to the retention of H2AK119ub1 at the regulatory loci of INK4B and PTEN and thereby the inactivation of these two well-known tumor suppressor genes in response to oncogenic signals, supporting ASXL1 as a tumor suppressor (Wu et al., 2015; Cao et al., 2020). Here, ASXL1 is linked to neoplasm.