INS and Glucose intolerance: HFD+SE-HFD offspring developed more severe glucose intolerance during IPGTT than CHOW+SHAM-HFD and CHOW+SE-HFD offspring (p < 0.05, Figure 1B); however, only CHOW+SHAM-HFD and HFD+SE-HFD offspring showed increased plasma insulin levels (Figure 1C).