Murota et al. (2016) analyzed 1,128 serum proteins from patients with RA, primary Sjogren’s syndrome and healthy patients by using SOMAScan. IL-16 showed the highest correlation with MMP-3 for using methotrexate to naïve and inadequate response RA patients based on synovitis status. On the other hand, considering that fluctuation of IL-16 was greatly associated with respond clinically when methotrexate or biologics were employed to treat RA, IL-6 was seen as a stronger clinical index than C-reactive protein, MMP-3 or erythrocyte sedimentation rate (Murota et al., 2016). Here, IL16 is linked to rheumatoid arthritis.