Accordingly, CXCL12-secreting MSCs have improved wound healing, dermal fibroblast migration and new blood vessel formation (Nakamura et al., 2013), whereas CXCR4-overexpressing MSCs improved the outcome of myocardial infarction by increasing cell engraftment and angiogenesis and reducing myocardial remodeling (Huang et al., 2010; Zhang D. et al., 2010). The gene discussed is CXCR4; the disease is myocardial infarction.