Obviously, effects mediated by VEGF-overexpressing MSCs are related to the potent pro-angiogenic capacity of this molecule that improves the blood flow and the heart function in preclinical assays of critical limb ischemia (Beegle et al., 2016) and myocardial infarction (Zhu et al., 2012), respectively. The gene discussed is VEGFA; the disease is myocardial infarction.