PAK1 phosphorylates β-catenin at S675 and S663 to stabilize β-catenin and translocate to nuclear, activating transcription of targeted genes, containing c-MYC, CCND1, and MMP, leading to promoted cancer progression and drug resistance (He et al., 2008; Huynh et al., 2015, 2016; Semenova et al., 2017). This evidence concerns the gene PAK1 and cancer.