The cross-talk between PAK1 and STAT5 signal transductions is extremely important for leukemia, and the cross-talk between Hippo/YAP and FAK/ILK/PAK1 cascades promotes cell cytoskeleton modulation in liver cancer (Chatterjee et al., 2014; Sabra et al., 2017; Yuanxin et al., 2019). This evidence concerns the gene PAK1 and leukemia.