NLRP3 and liver dysplastic nodule: In podocytes of DN mice induced by high-fat diet/streptozotocin (HFD/STZ), the number of autophagosomes decreased and the level of NLRP3 inflammasome expression and renal proinflammatory cytokines such as IL-1β increased, meanwhile, the similar results were obtained in human DN biopsies, suggesting that podocyte autophagy was inhibited and NLRP3 inflammasome was activated.