SETX and neoplasm: In addition, tumor cells induce the DNA/RNA helicase Senataxin (SETX) under radiobiological hypoxia, which inhibits cellular apoptosis assisted by the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/activating transcription factor 4 (ATF4) arm of the unfolded protein response (UPR) (Ramachandran et al., 2020).