In addition to upregulating the expression of glucose transporters and glycolytic enzymes required for glycolysis, HIF-1 inhibits mitochondrial oxidative phosphorylation by blocking pyruvate entry and the conversion of pyruvate to acetyl-CoA (Zeng et al., 2015), thus further stimulating glycolysis and promoting tumor cell survival even in acute and prolonged hypoxic conditions. Here, HIF1A is linked to neoplasm.