Further investigations of enriched KEGG pathways of IFI16, LMNB1, RHBDF2 and TACC3 in ccRCC showed that highly expressed genes [IFI16 (A), LMNB1 (B), RHBDF2 (C), and TACC3 (D)] were all enriched in T cell receptor signaling pathway, NK cell-mediated cytotoxicity, antigen processing and presentation and primary immunodeficiency. The gene discussed is RHBDF2; the disease is inborn error of immunity.