The ROC curve analysis revealed that these genes had good efficacies in the diagnosis of ccRCC (IFI16 protein AUC: 0.955, LMNB1 protein AUC: 0.959, RHBDF2 protein AUC: 0.94, TACC3 protein AUC: 0.915; Supplementary Figure 3B). The gene discussed is LMNB1; the disease is nonpapillary renal cell carcinoma.