The Kaplan-Meier survival analysis showed that higher expressions of IFI16 (p < 0.001, HR = 2.25, 95% CI: 1.63-3.1), LMNB1 (p < 0.001, HR = 1.71, 95% CI: 1.23-2.38), RHBDF2 (p < 0.001, HR = 2.26, 95% CI: 1.62-3.15) and TACC3 (p < 0.001, HR = 2.43, 95% CI: 1.74-3.41) predicted poor OS (Figures 8A–D), which were consistent with the Kaplan-Meier survival analysis results of CPTAC-ccRCC cohort (Supplementary Figure S6). The gene discussed is RHBDF2; the disease is nonpapillary renal cell carcinoma.