Furthermore, the ROC curve analysis showed that these hub genes had a high diagnostic value as biomarkers for TCGA ccRCC (IFI16 AUC: 0.921, LMNB1 AUC: 0.87, RHBDF2 AUC: 0.957, TACC3 AUC: 0.896; Supplementary Figure 3A). The gene discussed is IFI16; the disease is nonpapillary renal cell carcinoma.