Furthermore, the ROC curve analysis showed that these hub genes had a high diagnostic value as biomarkers for TCGA ccRCC (IFI16 AUC: 0.921, LMNB1 AUC: 0.87, RHBDF2 AUC: 0.957, TACC3 AUC: 0.896; Supplementary Figure 3A). Here, TACC3 is linked to nonpapillary renal cell carcinoma.