However, we recently reported that PVT1 exon 4B is significantly over expressed in prostate tumors with Gleason score ≥8 as compared to those with Gleason score ≤7 (16), suggesting that PVT1 exon 4B expression may be well suited for distinguishing between indolent and aggressive PCa. The gene discussed is PVT1; the disease is posterior cortical atrophy.