Since previous experiments found that high iodine can induce the proliferation of BCPAP and 8305C cells by activating AKT/Wee1/CDK1 axis, we discussed whether AKT/Wee1/CDK1 was involved in the tumor growth of xenograft tumor models of PTC and ATC cells induced by high iodine. The gene discussed is AKT1; the disease is neoplasm.