IHC analysis showed the ratio of p-AKT/AKT (P < 0.01, Figure 6A) and p-Wee1/Wee1 (P < 0.05, Figure 6B) in xenograft tumor models were significantly increased in I6000 μg/L groups compared to control groups, whereas the ratio of p-CDK1/CDK1 was significantly decreased in the I6000 μg/L group compared to control groups (P < 0.05, Figure 6C). Here, WEE1 is linked to neoplasm.