CDK6 and neoplasm: The main molecular mechanisms of miR-34a-mediated tumor suppression included, but were not limited to repressing cell proliferation (c-MYC, E2F, CDK4, and CDK6), promoting cell apoptosis (Bcl2, SITR1, and AXL), and inhibition of cell invasion and metastasis (c-MET, SNAIL, MMP9, CD44, and NOTCH1) (29, 31–34).