IL3RA and acute myeloid leukemia: Compared with AML blasts with normal IL-3Rα expression, AML blasts with elevated IL-3Rα expression showed robust Stat5 activation, a key transcription factor in IL-3 signaling, after IL-3 stimulation (13), suggesting the expression level of IL-3Rα is essential in IL-3-mediated AML cell proliferation.