MYCN and neuroblastoma: To elucidate the contribution of IGF2BP1 to protumorigenic phenotype of both low- and high-risk neuroblastoma cells, we employed three cell lines with varying expression of two genetic markers associated with poor prognosis, MYCN and IGF2BP1. The SK-N-AS cell line represents low-risk neuroblastoma, with barely detectable levels of MYCN and IG2BP1 expression.