To this aim, we used three different human neuroblastoma cell lines, SK-N-AS, SK-N-BE(2), and SK-N-DZ and employed both short hairpin RNA (shRNA)-mediated inducible knockdown or chemical inhibition of IGF2BP1 mRNA binding to test our hypothesis that suppressing IGF2BP1 activity would have a negative impact on cell growth and proliferation. This evidence concerns the gene IGF2BP1 and neuroblastoma.