SIGLEC8 and neoplasm: Analysis of a LUAD-specific RNA-seq dataset revealed results consistent with previously analyzed data, and that mRNA levels of SIGLEC1, CD22, CD33, MAG, SIGLEC5, SIGLEC6, SIGLEC7, SIGLEC8, SIGLEC9, SIGLEC11, SIGLEC14, and SIGLEC16 were downregulated in LUAD tumor tissues relative to normal tissues (p < 0.001) (Figure 1B).