CD22 and neoplasm: Analysis of genetic alteration frequency and types for the SIGLECs and according to tumor type (Figure 3B) showed that the alteration frequency ranged from 0.4 to 6%, with CD22 having the largest percentage change, followed by MAG. Additionally, amplifications occurred in CD22 and MAG, with mutations were the most common features and included truncation, missense, and in-frame mutations.