In the present study, we found that CD22, CD33, and SIGLEC1/5/6/7/8/9/10/11/14/15/16 were significantly negatively associated with tumor purity and significantly positively associated with B cell, CD8+ T cells, and CD4+ T cell infiltration and moderately (r > 0.3)-to-strongly (r > 0.5) correlated with neutrophil, macrophage, and dendritic cell infiltration. The gene discussed is CD8A; the disease is neoplasm.