APC and neoplasm: A high-throughput sequencing of the tumor described in both cases alteration in the Wnt/β-catenin pathway: a mutation in <i>CTNNB1</i> (exon 3, c.110C>G, p.S37C, reported as a hotspot in COSMIC) in one case and a homozygous loss associated with breakage targeting <i>APC</i> (5q22.2) in the second.