Results: We report a mean of 11.6 mutations/Mb with a characteristic smoking signature along with mutations in TP53 (65%), CDKN2A (20%), NFE2L2 (20%), FAT1 (15%), KMT2C (15%), LRP1B (15%), FGFR1 (14%), PTEN (10%) and PREX2(5%) among lung squamous cell carcinoma patients of Indian descent. The gene discussed is CDKN2A; the disease is squamous cell lung carcinoma.