Of them, ABC transporters, Adherens junction, cAMP signaling, and Taste transduction pathways were significant only in recurrent/metastatic samples, and extracellular matrix (ECM)-receptor interaction, Human papillomavirus infection, and PI3K-Akt signaling pathways were significant in both of primary and recurrent/metastatic samples. The gene discussed is AKT1; the disease is human papilloma virus infection.