By IHC, we found no differences in the infiltration of immune cells, however the recurrent/metastatic tumors had decreased expression of the antigen presenting genes, B2M, HLA-A, HLA-B, HLA-C, and HLA-DR, and the checkpoint molecule PDCD1 and increased CD274 expression compared to the primary tumors. The gene discussed is HLA-B; the disease is metastatic neoplasm.