NOTCH1 and metastatic neoplasm: Figure 2C demonstrates the high frequency of mutations in the top 20 driver genes. TP53 gene is the highest mutated driver gene in both sample groups. We further identified differential mutations in the driver genes between the primary and recurrent/metastatic tumors. In doing so, we identified that BRCA1 and NOTCH1 driver genes are highly mutated in primary samples, and PIK3CA, ARID1A, RASA1, TSC2, and ERBB4 were mutated higher in recurrent/metastatic compared with primary samples. Especially, CIC, KIF1A, LATS1, RARA, SPTAN1 genes only mutated in recurrent/metastatic samples (Figure 2D).