Auphen, an inhibitor of AQP3 that localize in the PVM between the host cell and the Plasmodium parasite reduces P. vivax liver hypnozoite and schizont burden, and inhibits P. vivax asexual blood-stage growth, and thus suggest that the AQP3 may be targeted for malaria treatment (Posfai et al., 2020). Here, AQP3 is linked to malaria.