In comparison with these previous mild cases, our study further demonstrated that these variants in the FHD [c.307C > T; p.(Arg103Cys), c.311A > C; p.(His104Pro), and c.320G > A; p.(Ser107Asn), and c.335T > A; p.(Phe112Tyr)] that surrounded the p.Asn109 of FOXL2 (the central portion of the FHD of FOXL2) lead to a rather severe BPES phenotype in another way. Here, FOXL2 is linked to blepharophimosis, ptosis, and epicanthus inversus syndrome.