Of all missense variants, the variants p.(Arg103Cys), p.(His104Pro), p.(Ser107Asn), and p.(Phe112Tyr) all failed to inhibit the StAR activity, of which the p.(Arg103Cys) mutant was consistent with the female patients manifesting infertility in the BPES type I family (Figure 3A). Here, STAR is linked to Infertility.