Meta−analysis using the fixed−effects model suggested higher prevalence of positive anti-TPO (OR=2.51, 95% CI, 1.56−4.06) and anti-Tg (OR=2.84, 95% CI, 1.30−6.23) antibodies in patients with pemphigus than healthy individuals (Figures 2A, B). The gene discussed is TG; the disease is pemphigus.