IL36RN and psoriasis: Indeed, mouse neonates with constitutive overexpression of IL-36α in keratin (KRT)14+ keratinocytes developed spontaneous skin disease with features specific of psoriasis, such as flaky skin, increased epidermal thickness, increased proliferation of basal keratinocytes and increased skin expression of Il1f5, Il36a, Il36b, Il36g, or Il23a (178).