Indeed, IL-36Ra-deficient mice developed more severe Aldara (5% IMQ)-induced dermatitis than WT mice (24, 118, 181), with increased ear (24, 118) and epidermal thickness (24, 118, 181), increased dermal infiltrated area (118), and increased numbers of skin-infiltrating CD45+ leukocytes and more specifically neutrophils (24). Here, IL36RN is linked to dermatitis.