After removing patients with only optic neuritis (ON) during a recent relapse, the sNfL levels were slightly increased in the AQP4-ab+NMOSD and MOGAD groups, and the difference of sNfL levels between AQP4-ab+NMOSD and RRMS groups diminished (p = 0.133) (Supplementary Figure 1). The gene discussed is AQP4; the disease is optic neuritis.