In contrast, genetic depletion of core components of inflammasomes, such as Nlrp3, Casp1, Casp11, and gasdermin D (Gsdmd), protects against septic shock (9–15) or lethal endotoxemia (7) in mice, turning them into a promising target for treatment of sepsis. The gene discussed is GSDMD; the disease is serum lipopolysaccharide activity.