Notably, STING1-mediated type I interferon (IFN) response does not seem to be important for inflammasome-mediated coagulation response during sepsis, because deletion of type I IFN receptor (Ifnar) or interferon regulatory factor 3 (Irf3) in mice fails to block infection-induced coagulation activation (62). This evidence concerns the gene STING1 and Sepsis.