Similarly, of the myriad of known neutrophil specific immunodeficiencies caused by genetic abnormalities linked to Candida infection, including Dectin-1, CD18, CARD9, MPO, and enzymes of the NADPH oxidase pathway (6), to date chitotriosidase has not been linked in an increase in fungal susceptibility (6, 27). Here, FMO5 is linked to immune system disorder.