SARS-CoV-2 requires both, the ACE2 receptor and TMPRSS2 for protein priming to enter the cell (4), while FURIN facilitates the active binding of SARS-CoV-2 through the ACE2 receptor (5), which is a risk factor for a more severe cause of COVID-19 (4, 6). The gene discussed is FURIN; the disease is COVID-19.