Pretreatment (24 h before infection) and simultaneous administration (simultaneously with infection) of EM703 drastically improved survival, reduced lung levels of proinflammatory cytokines (IL-6, MCP-1, KC, and TNFα), and decreased lungs damages and neutrophils infiltration in EM703 and levofloxacin treated mice. The gene discussed is CALCA; the disease is infection.