G6PC1 and Hypoglycemia: Predisposition to hypoglycemia is due to low glucose-6-phosphatase activity (31), the existence of an incompletely coordinated counter-regulatory system (32), increased basal metabolism of glucose, a lower capacity for production of alternative energy sources from their already insufficient stores (27), and presence of clinical conditions associated with hypoglycemia, such as perinatal asphyxia, hypoxia, sepsis, and hypothermia.