Given that ectopic PAF-AH expression in KS-Imm human Kaposi’s sarcoma cells, or B16F10 melanoma cells resulted in reduced neoangiogenesis and tumor growth in their respective SCID and C56Bl/6J hosts, and that IFNγ-stimulated PAF synthesis enhanced the invasiveness of F10-M3, a clone of B16F10 melanoma line (35, 36), the direct evidence of tumoral PAFR in melanoma growth remained unclear as unlike many human melanoma cell lines (37–40), murine B16F10 cells do not express PAFR (41, 42). The gene discussed is IFNG; the disease is melanoma.