Accumulation of TAR DNA-binding protein 43 (TDP-43), a nuclear protein implicated in the development of FTLD-TDP and ALS, has also been described in cases of repetitive brain trauma, with or without CTE diagnosis in humans (8, 25, 40–42), as well as animal models (43). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.