LOX and rheumatoid arthritis: The result indicates that Bacopa monniera Linn and its methanolic extracts may be a potential herbal product for treating joint inflammation and even RA when targeting LOX (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate (HOEC) is an important herbal ingredient product isolated from Incarvillea mairei var, which has long been used as folk medicine for the treatment of inflammatory related diseases in China.