ALOX15 and rheumatoid arthritis: Also, 15-HETE inhibits the mitogenesis of T-lymphocyte and the secretion of eosinophil leukotrienes C4 (LTC4), to prevent the neutrophil migration, and inhibit superoxide anion production and degranulation from activated neutrophil, which leads to the down-regulation of the inflammatory process in RA joints, indicating that 15-LOX has a protective effect on RA through forming the anti-inflammatory lipoxins (Wan et al., 2019).