PLA2G4A and rheumatoid arthritis: Then, the elevated cPLA2 acts as an important regulator of those key players including interleukin-8 (IL-8), prostaglandin E2 (PGE2), stromelysin-1 (matrix metalloproteinase 3, MMP3) and COX2 in the pathology of RA, which results in the destruction, angiogenesis of bone and cartilage and the neutrophil recruitment (Sommerfelt et al., 2013).