IL6 and rheumatoid arthritis: While PG201 reduces the protein expression of cPLA2, it does not affect the mRNA expression level of cPLA2, which leads to the decreased production of PGE2, thus declining the concentrations of IL-1β, IL-6 and CC chemokine ligand-2 (CCL2) in supernatant and synovial tissues, eventually plays important anti-inflammation and anti-arthritic activity in LPS induced inflammatory cells (Raw264.7 cell) and RA rat model (Shin et al., 2003; Choi et al., 2012).