Then, the elevated cPLA2 acts as an important regulator of those key players including interleukin-8 (IL-8), prostaglandin E2 (PGE2), stromelysin-1 (matrix metalloproteinase 3, MMP3) and COX2 in the pathology of RA, which results in the destruction, angiogenesis of bone and cartilage and the neutrophil recruitment (Sommerfelt et al., 2013). This evidence concerns the gene MMP3 and rheumatoid arthritis.