Administering sodium hydrosulfide (NaSH), at 2.8 mg/kg, once a day for 3 months ameliorated memory deficits, reduced APP and BACE1, upregulated the master regulator of antioxidant response genes, nuclear factor erythroid-2-related factor 2 (Nrf2), heme oxygenase-1(HO-1) and glutathione S-transferase (GST) in the APP/PS1 model of AD (Liu et al., 2016). This evidence concerns the gene HMOX1 and Alzheimer disease.