Consistent with this proposal, others have shown in a transgenic mouse model of AD, where APP and presenilin1 are overrexpressed, that blockade of Panx1 ameliorated synaptic defects in 6 months old APP/presenilin1 tg mice, and normalized LTP (Flores-Muñoz et al., 2020). This evidence concerns the gene PANX1 and Alzheimer disease.